Neuronal effects of glabellar botulinum toxin injections using a valenced inhibition task in borderline personality disorder.

ABSTRACT: Previous studies have indicated that glabellar botulinum toxin (BTX) injections may lead to a sustained alleviation of depression. This may be accomplished by the disruption of a facial feedback loop, which potentially mitigates the experience of negative emotions. Accordingly, glabellar BTX injection can attenuate amygdala activity in response to emotional stimuli. A prototypic condition with an excess of negative emotionality and impulsivity accompanied by elevated amygdala reactivity to emotional stimuli is borderline personality disorder (BPD). In order to improve the understanding of how glabellar BTX may affect the processing of emotional stimuli and impulsivity, we conducted a functional magnetic resonance imaging (fMRI) study. Our hypotheses were (1) glabellar BTX leads to increase

SUBMITTER: Kruger THC 

PROVIDER: S-EPMC9392726 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature