Bidirectional modulation of evoked synaptic transmission by pulsed infrared light.

ABSTRACT: Infrared (IR) neuromodulation (INM) has been demonstrated as a novel modulation modality of neuronal excitability. However, the effects of pulsed IR light on synaptic transmission have not been investigated systematically. In this report, the IR light (2 μm) is used to directly modulate evoked synaptic transmission at the crayfish opener neuromuscular junction. The extracellularly recorded terminal action potentials (tAPs) and evoked excitatory postsynaptic currents (EPSCs) modulated by localized IR light illumination (500 ms, 3-13 mW) aimed at the synapses are analyzed. The impact of a single IR light pulse on the presynaptic Ca²⁺ influx is monitored with Ca²⁺ indicators. The EPSC amplitude is enhanced, and its rising phase is accelerated under relatively low IR ligh

SUBMITTER: Zhu X 

PROVIDER: S-EPMC9392733 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature