A mannose-sensing AraC-type transcriptional activator regulates cell-cell aggregation of Vibrio cholerae.

ABSTRACT: In addition to catalyzing coupled transport and phosphorylation of carbohydrates, the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) regulates various physiological processes in most bacteria. Therefore, the transcription of genes encoding the PTS is precisely regulated by transcriptional regulators depending on substrate availability. As the distribution of the mannose-specific PTS (PTS^Man) is limited to animal-associated bacteria, it has been suggested to play an important role in host-bacteria interactions. In Vibrio cholerae, mannose is known to inhibit biofilm formation. During host infection, the transcription level of the V. cholerae gene encoding the putative PTS^Man (hereafter referred to as manP) significantly increases, and mutations in thi

SUBMITTER: Lee HY 

PROVIDER: S-EPMC9392796 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature