Spatial delivery of immune cues to lymph nodes to define therapeutic outcomes in cancer vaccination.

ABSTRACT: Recently approved cancer immunotherapies - including CAR-T cells and cancer vaccination, - show great promise. However, these technologies are hindered by the complexity and cost of isolating and engineering patient cells ex vivo. Lymph nodes (LNs) are key tissues that integrate immune signals to coordinate adaptive immunity. Directly controlling the signals and local environment in LNs could enable potent and safe immunotherapies without cell isolation, engineering, and reinfusion. Here we employ intra-LN (i.LN.) injection of immune signal-loaded biomaterial depots to directly control cancer vaccine deposition, revealing how the combination and geographic distribution of signals in and between LNs impact anti-tumor response. We show in healthy and diseased mice that relative

SUBMITTER: Andorko JI 

PROVIDER: S-EPMC9392868 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature