Identification of factors associated with residual malaria transmission using school-based serological surveys in settings pursuing elimination.

ABSTRACT:

Background

Targeted research on residual malaria transmission is important to improve strategies in settings pursuing elimination, where transmission reductions prove challenging. This study aimed to detect and characterize spatial heterogeneity and factors associated with Plasmodium falciparum infections and exposure, P. falciparum apical membrane antigen 1 (PfAMA1) antibody (Ab) response, in the Central Highlands of Madagascar (CHL).

Methods

From May to July 2014, a cross-sectional school-based survey was carried out in 182 fokontany (villages) within 7 health districts of the CHL. Rapid diagnostic tests (RDTs) and a bead-based immunoassay including PfAMA1 antigen biomarker were used to estimate malaria prevalence and seroprevalence, respectively. Local Moran's I index was

SUBMITTER: Rakotondramanga JM 

PROVIDER: S-EPMC9392911 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature