A novel ferroptosis-related gene signature can predict prognosis and influence immune microenvironment in acute myeloid leukemia.

ABSTRACT: Acute myeloid leukemia (AML) is a highly heterogeneous hematopoietic malignancy that strongly correlates with poor clinical outcomes. Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death which plays an important role in various human cancers. Nevertheless, the prognostic significance and functions of ferroptosis-related genes (FRGs) in AML have not received sufficient attention. The aim of this article was to evaluate the association between FRGs levels and AML prognosis using publicly available RNA-sequencing datasets. The univariate Cox regression analysis identified 20 FRGs that correlate with patient overall survival. The LASSO Cox regression model was used to construct a prognostic 12-gene risk model using a TCGA cohort, and internal and external validation pro

SUBMITTER: Huang X 

PROVIDER: S-EPMC9392974 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature