CM-352 Efficacy in a Mouse Model of Anticoagulant-Associated Intracranial Hemorrhage.

ABSTRACT:

Background

 Intracranial hemorrhage (ICH) is one of the major devastating complications of anticoagulation. Matrix metalloproteinase (MMP) inhibition has been proposed as a novel pharmacological approach for ICH treatment.

Objectives

 We evaluated the effects of CM-352 (MMP-fibrinolysis inhibitor) in an experimental ICH model associated with oral anticoagulants as compared with clinically used prothrombin complex concentrate (PCC).

Methods

 ICH was induced by collagenase injection into the striatum of wild type (C57BL/6J) anticoagulated mice (warfarin or rivaroxaban) and Mmp10 -/- mice. Hematoma volume and neurological deficits were measured 24 hours later by diaminobenzidine staining and different behavioral tests. Circulating plasminogen activator inhi

SUBMITTER: Navarro-Oviedo M 

PROVIDER: S-EPMC9393087 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature