Construction of a breast cancer prognosis model based on alternative splicing and immune infiltration.

ABSTRACT:

Background

Breast cancer (BC) is the most common malignancy among women in the world. Alternative splicing (AS) is an important mechanism for regulating gene expression and producing proteome diversity, which is closely related to tumorigenesis. Understanding the role of AS in BC may be helpful to reveal new therapeutic targets for clinical interventions.

Methods

RNA-seq, clinical and AS data of TCGA-BRCA were downloaded from TCGA and TCGA SpliceSeq databases. AS events associated with prognosis were filtered by univariate Cox regression. The AS risk model of BC was built by Lasso regression, random forest and multivariate Cox regression. The accuracy of the AS risk model and clinicopathological factors were evaluated by time-dependent receiver operating characteristic (ROC)

SUBMITTER: Zhang D 

PROVIDER: S-EPMC9393119 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature