Prognostic significance of additional histologic features for subclassification of pathological T3 colon cancer.

ABSTRACT:

Background

Additional histologic features of T3 colon cancer, such as tumour depth invasion beyond muscularis propria and elastic lamina invasion (ELI), have taken interest for a more accurate staging.

Methods

Patients with pT3 and pT4a (control group) colon adenocarcinoma were retrospectively collected from our institutional database. The study group was divided according to depth of tumour invasion < 5 mm and ≥ 5 mm, and into ELI - and ELI + . Chi-square test was used to compare the clinicopathological characteristics. OS and DFS were estimated using Kaplan-Meier method and compared with the log-rank test. Univariable and multivariable Cox proportional hazard models were employed to assess the effect on OS and DFS.

Results

Out of 290 pT3 tumours, 168 (58%) had a dep

SUBMITTER: Macchi L 

PROVIDER: S-EPMC9393148 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature