Changes of thoracic duct flow and morphology in an animal model of elevated central venous pressure.

ABSTRACT: Objective: Investigation of lymph fluid dynamics in thoracic duct during central venous pressure elevation. Background: Lymphatic flow is affected by elevated central venous pressure (CVP) in congestive heart failure. The changes of thoracic duct (TD) lymph flow have not been studied chronically in the setting of elevated CVP. This study is to investigate fluid dynamics and remodeling of the TD in the elevated CVP animal model. Methods: A flow probe was implanted on the swine TD (n = 6) and tricuspid regurgitation (TR) was created by cutting tricuspid chordae percutaneously. Six swine were used as control group animals. The TD flow was measured for 2 weeks (baseline) before TR and 4 weeks postop-TR surgery. Arterial pressure and CVP were measured. The pressure a

SUBMITTER: Lu X 

PROVIDER: S-EPMC9393243 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature