Time-series transcriptome analysis identified differentially expressed genes in broiler chicken infected with mixed Eimeria species.

ABSTRACT: Coccidiosis caused by the Eimeria species is a highly problematic disease in the chicken industry. Here, we used RNA sequencing to observe the time-dependent host responses of Eimeria-infected chickens to examine the genes and biological functions associated with immunity to the parasite. Transcriptome analysis was performed at three time points: 4, 7, and 21 days post-infection (dpi). Based on the changes in gene expression patterns, we defined three groups of genes that showed differential expression. This enabled us to capture evidence of endoplasmic reticulum stress at the initial stage of Eimeria infection. Furthermore, we found that innate immune responses against the parasite were activated at the first exposure; they then showed gradual normalization. Although

SUBMITTER: Kim M 

PROVIDER: S-EPMC9393255 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature