Human leukocyte antigen class II gene diversity tunes antibody repertoires to common pathogens.

ABSTRACT: Allelic diversity of human leukocyte antigen (HLA) class II genes may help maintain humoral immunity against infectious diseases. In this study, we investigated germline genetic variation in classical HLA class II genes and employed a systematic, unbiased approach to explore the relative contribution of this genetic variation in the antibody repertoire to various common pathogens. We leveraged a well-defined cohort of 800 adults representing the general Arab population in which genetic material is shared because of the high frequency of consanguineous unions. By applying a high-throughput method for large-scale antibody profiling to this well-defined cohort, we were able to dissect the overall effect of zygosity for classical HLA class II genes, as well as the effects associated with speci

SUBMITTER: Khan T 

PROVIDER: S-EPMC9393332 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature