Associations between rs3480 and rs16835198 gene polymorphisms of FNDC5 with type 2 diabetes mellitus susceptibility: a meta-analysis.

ABSTRACT:

Background

FNDC5 is a novel and important player in energy regulation related to glucose metabolism and insulin levels. Thus, it may affect the incidence of type 2 diabetes mellitus (T2DM). Nevertheless, the association between FNDC5 single nucleotide polymorphisms (SNPs) and susceptibility to T2DM remains unclear. The aim of this meta-analysis was to explore whether the SNPs, rs3480 and rs16835198, are associated with the risk of T2DM.

Methods

Studies published before February 1^st, 2022 were screened to identify the included studies. R software was also applied for calculation of odds ratio (OR), 95% confidence interval (95% CI), heterogeneity, and sensitivity analysis.

Results

Seven studies for rs3480 (involving 5475 patients with T2DM and 4855 healthy co

SUBMITTER: Yang X 

PROVIDER: S-EPMC9393395 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature