Circulating MicroRNAs and myocardial involvement severity in chronic Chagas cardiomyopathy.

ABSTRACT:

Background

Chronic Chagas Cardiomyopathy (CCM) is characterized by a unique pathophysiology in which inflammatory, microvascular and neuroendocrine processes coalesce in the development of one of the most severe cardiomyopathies affecting humans. Despite significant advances in understanding the molecular mechanisms involved in this disease, scarce information is available regarding microRNAs and clinical parameters of disease severity. We aimed to evaluate the association between circulating levels of six microRNAs with markers of myocardial injury and prognosis in this population.

Methods

Patients with CCM and reduced ejection fraction were included in a prospective exploratory cohort study. We assessed the association of natural log-transformed values of six circulating m

SUBMITTER: Gomez-Ochoa SA 

PROVIDER: S-EPMC9393411 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature