Chronic stability of activated iridium oxide film voltage transients from wireless floating microelectrode arrays.

ABSTRACT: Successful monitoring of the condition of stimulation electrodes is critical for maintaining chronic device performance for neural stimulation. As part of pre-clinical safety testing in preparation for a visual prostheses clinical trial, we evaluated the stability of the implantable devices and stimulation electrodes using a combination of current pulsing in saline and in canine visual cortex. Specifically, in saline we monitored the stability and performance of 3000 μm² geometric surface area activated iridium oxide film (AIROF) electrodes within a wireless floating microelectrode array (WFMA) by measuring the voltage transient (VT) response through reverse telemetry. Eight WFMAs were assessed in vitro for 24 days, where n = 4 were pulsed continuously at 80 μA (16

SUBMITTER: Frederick RA 

PROVIDER: S-EPMC9393423 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature