A machine learning model for predicting patients with major depressive disorder: A study based on transcriptomic data.

ABSTRACT:

Background

Identifying new biomarkers of major depressive disorder (MDD) would be of great significance for its early diagnosis and treatment. Herein, we constructed a diagnostic model of MDD using machine learning methods.

Methods

The GSE98793 and GSE19738 datasets were obtained from the Gene Expression Omnibus database, and the limma R package was used to analyze differentially expressed genes (DEGs) in MDD patients. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to identify potential molecular functions and pathways. A protein-protein interaction network (PPI) was constructed, and hub genes were predicted. Random forest (RF) and artificial neural network (ANN) machine-learning algorithms were used to select variabl

SUBMITTER: Liu S 

PROVIDER: S-EPMC9393475 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature