Alterations in the vaginal microbiota of patients with preterm premature rupture of membranes.

ABSTRACT:

Background

Preterm premature rupture of membranes (PPROM) is a common pregnancy complication. Yet, the main cause of PPROM remains poorly understood. In this study, we used 16S rRNA gene sequencing technology to identify the differences in vaginal microbiota between pregnant women with PPROM and those who delivered at term.

Methods

Vaginal samples were collected from 48 patients with PPROM and 54 age- and gestational age-matched pregnant women who delivered at term (controls). The vaginal microbiota of the two groups was compared using 16S rRNA gene sequencing of the V3-V4 regions.

Results

The vaginal microbial composition of the PPROM group was significantly different from that of the control group. Our results showed that the diversity of vaginal microbiota in patie

SUBMITTER: Yan C 

PROVIDER: S-EPMC9393476 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature