Small non-coding RNA landscape of extracellular vesicles from a post-traumatic model of equine osteoarthritis.

ABSTRACT: Extracellular vesicles comprise an as yet inadequately investigated intercellular communication pathway in the field of early osteoarthritis. We hypothesised that the small non-coding RNA expression pattern in synovial fluid and plasma would change during progression of experimental osteoarthritis. In this study, we conducted small RNA sequencing to provide a comprehensive overview of the temporal expression profiles of small non-coding transcripts carried by extracellular vesicles derived from plasma and synovial fluid for the first time in a posttraumatic model of equine osteoarthritis. Additionally, we characterised synovial fluid and plasma-derived extracellular vesicles with respect to quantity, size, and surface markers. The different temporal expressions of seven microRNAs in plasma

SUBMITTER: Anderson JR 

PROVIDER: S-EPMC9393553 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature