Detailed spatial immunophenotyping of primary melanomas reveals immune cell subpopulations associated with patient outcome.

ABSTRACT: While the tumor immune microenvironment (TIME) of metastatic melanoma has been well characterized, the primary melanoma TIME is comparatively poorly understood. Additionally, although the association of tumor-infiltrating lymphocytes with primary melanoma patient outcome has been known for decades, it is not considered in the current AJCC melanoma staging system. Detailed immune phenotyping of advanced melanoma has revealed multiple immune biomarkers, including the presence of CD8+ T-cells, for predicting response to immunotherapies. However, in primary melanomas, immune biomarkers are lacking and CD8+ T-cells have yet to be extensively characterized. As recent studies combining immune features and clinicopathologic characteristics have created more accurate predictive models, this study s

SUBMITTER: Attrill GH 

PROVIDER: S-EPMC9393646 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature