Molecular Epidemiology and Hematologic Characterization of Thalassemia in Guangdong Province, Southern China.

ABSTRACT: Introduction: About 2% of the population in the world are carriers of the thalassemia gene. Thalassemia is highly prevalent in Southern China, and traditional clinical testing methods would cause missed diagnosis of partial static thalassemia. Here, we reviewed and summarized a set of simple and clinically feasible thalassemia detection protocols adopted by the Prenatal Diagnosis and Reproductive Center of our hospital. Methods: From January 1, 2015, to December 31, 2020, 31 512 peripheral blood samples and 3828 prenatal samples were collected in our study. All the peripheral blood samples were performed through thalassemia screening by routine blood tests and hemoglobin electrophoresis and gene detection. The prenatal diagnosis would be implemented for the fetus if the paren

SUBMITTER: Xian J 

PROVIDER: S-EPMC9393661 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature