Impaired quality of life, but not cognition, is linked to a history of chronic hypercortisolism in patients with Cushing's disease in remission.

ABSTRACT:

Context

Impaired cognition and altered quality of life (QoL) may persist despite long-term remission of Cushing's disease (CD). Persistent comorbidities and treatment modalities may account for cognitive impairments. Therefore, the role of hypercortisolism per se on cognitive sequelae remains debatable.

Objective

To investigate whether memory and QoL are impaired after long-term remission of CD in patients with no confounding comorbidity.

Design and setting

Cross-sectional case-control study in two tertiary referral centers.

Patients

25 patients (44.5 ± 2.4 years) in remission from CD for 102.7 ± 19.3 Mo and 25 well-matched controls, without comorbidity or treatment liable to impair cognition.

Main outcome measures

Hippocampus- and prefrontal cort

SUBMITTER: Pupier E 

PROVIDER: S-EPMC9393704 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature