PTPRO-related CD8⁺ T-cell signatures predict prognosis and immunotherapy response in patients with breast cancer.

ABSTRACT:

Background

Poor immunogenicity and extensive immunosuppressive T-cell infiltration in the tumor immune microenvironment (TIME) have been identified as potential barriers to immunotherapy success in "immune-cold" breast cancers. Thus, it is crucial to identify biomarkers that can predict immunotherapy efficacy. Protein tyrosine phosphatase receptor type O (PTPRO) regulates multiple kinases and pathways and has been implied to play a regulatory role in immune cell infiltration in various cancers.

Methods

ESTIMATE and single-sample gene set enrichment analysis (ssGSEA) were performed to uncover the TIME landscape. The correlation analysis of PTPRO and immune infiltration was performed to characterize the immune features of PTPRO. Univariate and multivariate Cox analyses were ap

SUBMITTER: Dong H 

PROVIDER: S-EPMC9393709 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature