Dynamic Hippocampal CA2 Responses to Contextual Spatial Novelty.

ABSTRACT: Hippocampal place cells are functional units of spatial navigation and are present in all subregions: CA1, CA2, CA3, and CA4. Recent studies on CA2 have indicated its role in social and contextual memories, but its contribution to spatial novelty detection and encoding remains largely unknown. The current study aims to uncover how CA2 processes spatial novelty and to distinguish its functional role towards the same from CA1. Accordingly, a novel 3-day paradigm was designed where animals were introduced to a completely new environment on the first day, and on subsequent days, novel segments were inserted into the existing spatial environment while the other segments remained the same, allowing us to compare novel and familiar parts of the same closed-loop track on multiple days. We found th

SUBMITTER: Bhasin G 

PROVIDER: S-EPMC9393711 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature