N⁶-Methyladenosine regulator RBM15B acts as an independent prognostic biomarker and its clinical significance in uveal melanoma.

ABSTRACT: Uveal melanoma (UM) is the most frequent intraocular malignant tumor in adults. N⁶-Methyladenosine (m⁶A) methylation is recognized as the most critical epigenetic change and is implicated in the development of many malignancies. However, its prognostic value in UM is poorly understood. RNA-seq and clinical data from The Cancer Genome Atlas (TCGA) help us better understand the relationship between m⁶A regulators and UM patients. Herein, four UM groups established by consensus clustering were shown to have different immune cell infiltrations and prognostic survival. Five m⁶A regulators, including RBM15B, IGF2BP1, IGF2BP2, YTHDF3, and YTHDF1, were associated with the prognosis of UM patients. Intriguingly, RBM15B was confirmed to be the only indepen

SUBMITTER: Wang T 

PROVIDER: S-EPMC9393712 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature