Textural features reflecting local activity of the hippocampus improve the diagnosis of Alzheimer's disease and amnestic mild cognitive impairment: A radiomics study based on functional magnetic resonance imaging.

ABSTRACT:

Background

Textural features of the hippocampus in structural magnetic resonance imaging (sMRI) images can serve as potential diagnostic biomarkers for Alzheimer's disease (AD), while exhibiting a relatively poor discriminant performance in detecting early AD, such as amnestic mild cognitive impairment (aMCI). In contrast to sMRI, functional magnetic resonance imaging (fMRI) can identify brain functional abnormalities in the early stages of cerebral disorders. However, whether the textural features reflecting local functional activity in the hippocampus can improve the diagnostic performance for AD and aMCI remains unclear. In this study, we combined the textural features of the amplitude of low frequency fluctuation (ALFF) in the slow-5 frequency band and structural images in the

SUBMITTER: Wang L 

PROVIDER: S-EPMC9393721 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature