Prediction of BRAF mutation status in glioblastoma multiforme by preoperative ring enhancement appearances on MRI.

ABSTRACT:

Background

Ring enhancement on magnetic resonance imaging (MRI) is an important characteristic of GBM. Though patients suffering from glioblastoma multiforme (GBM) with BRAF mutation (MUT BRAF) in V600E benefit from BRAF-targeted inhibitors, the relationship between ring enhancement and MUT BRAF remains elusive. The purpose of this study was to investigate the relationship between BRAF mutation status and the appearance of ring enhancement so as to guide preoperative targeted therapy for MUT BRAF GBM.

Methods

Patient's population, clinical data and characteristic ring enhancement appearances on MRI were compared between GBM with MUT BRAF and GBM with WT BRAF. A receiver operating characteristic (ROC) curve analysis was performed to evaluate the differential diagnostic signif

SUBMITTER: Cai X 

PROVIDER: S-EPMC9393738 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature