Association of cardiovascular risk factors and lifestyle behaviors with aortic aneurysm: A Mendelian randomization study.

ABSTRACT: Objective: To examine the causality between hypertension, diabetes, other cardiovascular risk factors, lifestyle behaviors, and the aortic aneurysm among patients of European ancestry. Methods: We performed two-sample Mendelian randomization (MR) analysis to investigate the causality of 12 modifiable risk factors with aortic aneurysm, including hypertension, body mass index (BMI), waist-hip ratio (WHR), diabetes, tobacco smoking, alcohol and coffee consumption, physical activity, and sleep duration. Genome-wide significant genetic instruments (p < 5 × 10^-8) for risk factors were extracted from European-descent genome-wide association studies, whereas aortic aneurysm genetic instruments were selected from the UK Biobank and FinnGen cohort. The inverse-varianc

SUBMITTER: Zhou J 

PROVIDER: S-EPMC9393757 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature