Mesenchymal stem cells establish a pro-regenerative immune milieu after decellularized rat uterus tissue transplantation.

ABSTRACT: Decellularized tissue is generally considered immune privileged after transplantation and is an attractive scaffold type for tissue regeneration, including applications for infertility treatment. However, the immune response following transplantation of decellularized tissue is insufficiently studied, in particular after they have been recellularized with mesenchymal stem cells (MSCs). Therefore, we replaced a large uterus segment with a bioengineered graft developed from decellularized uterus tissue and analyzed the immune response during the first 4 months in acellular or MSCs-recellularized scaffolds in the rat. Immunohistochemistry-stained infiltrating immune cells and plasma levels for 16 cytokines and chemokines were quantified. Results revealed that MSCs created an advantageous micr

SUBMITTER: Sehic E 

PROVIDER: S-EPMC9393937 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature