Evolution of intra-tumoral heterogeneity across different pathological stages in papillary thyroid carcinoma.

ABSTRACT:

Background

Intra-tumor heterogeneity (ITH) results from the continuous accumulation of mutations during disease progression, thus impacting patients' clinical outcome. How the ITH evolves across papillary thyroid carcinoma (PTC) different tumor stages is lacking.

Methods

We used the whole-exome sequencing data from The Cancer Genome Atlas Thyroid Cancer (TCGA-THCA) cohort to track the ITH and assessed its relationship with clinical features through different stages of the PTC progression. We further assayed the expression levels of the specific genes in papillary thyroid cancer cell lines compared to an immortalized normal thyroid epithelial cell line by qRT-PCR.

Results

We revealed the timing of mutational processes and the dynamics of the temporal acquisition of som

SUBMITTER: Affinito O 

PROVIDER: S-EPMC9394008 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature