Effect of invasive mechanical ventilation on the diversity of the pulmonary microbiota.

ABSTRACT: Pulmonary microbial diversity may be influenced by biotic or abiotic conditions (e.g., disease, smoking, invasive mechanical ventilation (MV), etc.). Specially, invasive MV may trigger structural and physiological changes in both tissue and microbiota of lung, due to gastric and oral microaspiration, altered body posture, high O₂ inhalation-induced O₂ toxicity in hypoxemic patients, impaired airway clearance and ventilator-induced lung injury (VILI), which in turn reduce the diversity of the pulmonary microbiota and may ultimately lead to poor prognosis. Furthermore, changes in (local) O₂ concentration can reduce the diversity of the pulmonary microbiota by affecting the local immune microenvironment of lung. In conclusion, systematic literature studies hav

SUBMITTER: Liu C 

PROVIDER: S-EPMC9394019 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature