Non-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study.

ABSTRACT:

Background

The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospective association of non-alcoholic fatty liver degree as well as NAFLD with incident IBS in a large-scale population-based cohort.

Methods

Participants free of IBS, coeliac disease, inflammatory bowel disease, alcoholic liver disease, and any cancer at baseline from the UK Biobank were included. Non-alcoholic fatty liver degree was measured by a well-validated fatty liver index (FLI), with FLI ≥ 60 as an indicator of NAFLD. Primary outcome was incident IBS. Cox proportional hazard model was used to investigate the associated risk of incident IBS.

Results

SUBMITTER: Wu S 

PROVIDER: S-EPMC9394037 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature