Lateral Hypothalamus Calcium/Calmodulin-Dependent Protein Kinase II α Neurons Encode Novelty-Seeking Signals to Promote Predatory Eating.

ABSTRACT: Predatory hunting is an innate appetite-driven and evolutionarily conserved behavior essential for animal survival, integrating sequential behaviors including searching, pursuit, attack, retrieval, and ultimately consumption. Nevertheless, neural circuits underlying hunting behavior with different features remain largely unexplored. Here, we deciphered a novel function of lateral hypothalamus (LH) calcium/calmodulin-dependent protein kinase II α (CaMKIIα ⁺) neurons in hunting behavior and uncovered upstream/downstream circuit basis. LH CaMKIIα ⁺ neurons bidirectionally modulate novelty-seeking behavior, predatory attack, and eating in hunting behavior. LH CaMKIIα ⁺ neurons integrate hunting-related novelty-seeking information fro

SUBMITTER: Tan N 

PROVIDER: S-EPMC9394055 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature