Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells.

ABSTRACT:

Background

Endothelial dysfunction is a critical component in the pathogenesis of cardiovascular diseases and is closely associated with nitric oxide (NO) levels and oxidative stress. Here, we report on novel findings linking endothelial expression of CD70 (also known as CD27 ligand) with alterations in NO and reactive oxygen species.

Methods

CD70 expression was genetically manipulated in human aortic and pulmonary artery endothelial cells. Intracellular NO and hydrogen peroxide (H₂O₂) were measured using genetically encoded biosensors, and cellular phenotypes were assessed.

Results

An unbiased phenome-wide association study demonstrated that polymorphisms in CD70 associate with vascular phenotypes. Endothelial cells treated with CD70-directed sh

SUBMITTER: Pandey AK 

PROVIDER: S-EPMC9394499 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature