Papillary renal cell carcinoma: current and controversial issues.

ABSTRACT:

Purpose of the review

Papillary renal cell carcinoma (pRCC) is the second most frequent renal cancer subtype and represents 15-20% of all RCC. Classification of pRCC is changing because novel tumour entities have been discovered in the last years. In this review, we summarise recent studies relevant for the understanding of the molecular complexity and the broader differential diagnosis of pRCC.

Recent findings

It has been 25 years ago, that pRCC was morphologically subdivided into type 1 and type 2. Recently described tumour entities in the 2022 WHO classification challenged this concept and allow a new view on the molecular background in pRCC. Biphasic hyalinizing psammomatous RCC and papillary renal neoplasm with reversed polarity are emerging tumour entities derived from

SUBMITTER: Angori S 

PROVIDER: S-EPMC9394504 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature