Cortical plasticity in phantom limb pain: A fMRI study on the neural correlates of behavioral clinical manifestations.

ABSTRACT: The neural mechanism of phantom limb pain (PLP) is related to the intense brain reorganization process implicating plasticity after deafferentation mostly in sensorimotor system. There is a limited understanding of the association between the sensorimotor system and PLP. We used a novel task-based functional magnetic resonance imaging (fMRI) approach to (1) assess neural activation within a-priori selected regions-of-interested (motor cortex [M1], somatosensory cortex [S1], and visual cortex [V1]), (2) quantify the cortical representation shift in the affected M1, and (3) correlate these changes with baseline clinical characteristics. In a sample of 18 participants, we found a significantly increased activity in M1 and S1 as well as a shift in motor cortex representation that was not relat

SUBMITTER: Duarte D 

PROVIDER: S-EPMC9394643 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature