A bidirectional Mendelian randomization study supports the causal effects of a high basal metabolic rate on colorectal cancer risk.

ABSTRACT:

Purpose

We conducted a bidirectional two-sample Mendelian randomization (MR) study to determine whether genetically predicted basal metabolic rate (BMR) was a causal risk factor for colorectal cancer (CRC) or whether a genetically predicted CRC risk can influence the BMR level (i.e., reverse causation).

Methods

We employed 1,040 genetic variants as proxies for BMR to obtain effect estimates on CRC risk. Another 58 CRC-associated variants were used to estimate effects on BMR levels. Stratified analysis by tumor site was used to examine the causal associations between BMR and colon/rectal cancer risk.

Results

The inverse variance weighted (IVW) method indicated a significant causal effect of genetically determined BMR on CRC risk (ORSD = 1.27, 95% CI = 1.07-1.51). No si

SUBMITTER: Wu E 

PROVIDER: S-EPMC9394792 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature