Relationship between liver dysfunction, lipoprotein concentration and mortality during sepsis.

ABSTRACT:

Background

High-density lipoproteins (HDLs) are synthesized by the liver and display endothelioprotective properties, including anti-inflammatory, antiapoptotic, antithrombotic and antioxidant effects. In both septic and chronic liver failure patients, a low HDL cholesterol (HDL-C) concentration is associated with overmortality. Whereas sepsis-associated liver dysfunction is poorly defined, the aim of this study was to characterize the relationship between liver dysfunction, lipoprotein concentrations and mortality in septic patients in the intensive care unit (ICU).

Methods

A prospective observational study was conducted in a university hospital ICU. All consecutive patients admitted for septic shock or sepsis were included. Total cholesterol, HDL-C, low-density lipoprotein

SUBMITTER: Tanaka S 

PROVIDER: S-EPMC9394828 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature