Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection.

ABSTRACT:

Objectives

Elevated plasma levels of sCD14 predict all-cause mortality in people with HIV (PWH). Epigenetic regulation plays a key role in infection and inflammation. To reveal the epigenetic relationships between sCD14, immune function and disease progression among PWH, we conducted an epigenome-wide association study (EWAS) of sCD14 and investigated the relationship with mortality.

Design and methods

DNA methylation (DNAm) levels of peripheral blood samples from PWH in the Veterans Aging Cohort Study (VACS) were measured using the Illumina Infinium Methylation 450K (n = 549) and EPIC (850K) BeadChip (n = 526). Adjusted for covariates and multiple testing, we conducted an epigenome-wide discovery, replication, and meta-analysis to identify significant associations with sCD1

SUBMITTER: Titanji BK 

PROVIDER: S-EPMC9394925 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature