Genomic Studies Across the Lifespan Point to Early Mechanisms Determining Subcortical Volumes.

ABSTRACT:

Background

Subcortical brain structures play a key role in pathological processes of age-related neurodegenerative disorders. Mounting evidence also suggests that early-life factors may have an impact on the development of common late-life neurological diseases, including genetic factors that can influence both brain maturation and neurodegeneration.

Methods

Using large population-based brain imaging datasets across the lifespan (N ≤ 40,628), we aimed to 1) estimate the heritability of subcortical volumes in young (18-35 years), middle (35-65 years), and older (65+ years) age, and their genetic correlation across age groups; 2) identify whether genetic loci associated with subcortical volumes in older persons also show associations in early adulthood, and explore underlying

SUBMITTER: Le Grand Q 

PROVIDER: S-EPMC9395126 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature