Successful treatment of recurrent cardiac sarcoidosis with the combination of corticosteroid and methotrexate monitored by ¹⁸F-fluoro-2-deoxyglucose positron emission tomography: case series.

ABSTRACT:

Background

The standard treatment for cardiac sarcoidosis (CS) is corticosteroids, including prednisolone (PSL). Previous studies have shown that the addition of methotrexate (MTX) to PSL is effective for steroid-refractory and recurrent cases. ¹⁸F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is an essential tool for the diagnosis of CS. However, it is unclear whether FDG-PET is useful for detecting recurrence of CS and monitoring the effectiveness of PSL and MTX combination therapy.

Case summary

We detected CS recurrence during PSL treatment using FDG-PET. Patient 1 was accompanied by increased FDG uptake in other organs, Patient 2 was complicated with a decrease in left ventricular ejection fraction, and Patient 3 showed enlargement of the late g

SUBMITTER: Ishizuka M 

PROVIDER: S-EPMC9395136 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature