AP-1 transcription factor network explains diverse patterns of cellular plasticity in melanoma cells.

ABSTRACT: Cellular plasticity associated with fluctuations in transcriptional programs allows individual cells in a tumor to adopt heterogeneous differentiation states and switch phenotype during their adaptive responses to therapies. Despite increasing knowledge of such transcriptional programs, the molecular basis of cellular plasticity remains poorly understood. Here, we combine multiplexed transcriptional and protein measurements at population and single-cell levels with multivariate statistical modeling to show that the state of AP-1 transcription factor network plays a unifying role in explaining diverse patterns of plasticity in melanoma. We find that a regulated balance among AP-1 factors cJUN, JUND, FRA2, FRA1, and cFOS determines the intrinsic diversity of differentiation states and adapti

SUBMITTER: Comandante-Lou N 

PROVIDER: S-EPMC9395172 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature