Ultrasensitive voltammetric detection of SARS-CoV-2 in clinical samples.

ABSTRACT: In every pandemic, it is critical to test as many people as possible and keep track of the number of new cases of infection. Therefore, there is a need for novel, fast and unambiguous testing methods. In this study, we designed a sandwich-type voltammetric immunosensor based on unlabeled- and labeled with a redox probe antibodies against virus spike protein for fast and ultrasensitive detection of SARS-CoV-2. The process of the preparation of the sensor layer included chemisorption of cysteamine layer and covalent anchoring of antibody specific for the S1 subunit of the S protein. The source of the voltametric signal was the antibody labeled with the redox probe, which was introduced onto biosensor surface only after the recognition of the virus. This easy-to-handle immunosensor was charac

SUBMITTER: Kowalczyk A 

PROVIDER: S-EPMC9395233 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature