Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight.

ABSTRACT:

Background/objectives

Central insulin action influences cognitive processes, peripheral metabolism, and eating behavior. However, the contribution of obesity and sex on central insulin-mediated neural food cue processing still remains unclear.

Subjects/methods

In a randomized within-participant design, including two visits, 60 participants (30 women, BMI 18-32 kg/m², age 21-69 years) underwent a functional MRI task measuring blood oxygen level-dependent (BOLD) signal in response to visual food cues after intranasal insulin or placebo spray administration. Central insulin action was defined as the neural BOLD response to food cues after insulin compared to placebo administration. Afterwards, participants were asked to rate the food cues for desire to eat (i.e., wan

SUBMITTER: Wagner L 

PROVIDER: S-EPMC9395264 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature