Decoding the effects of spike receptor binding domain mutations on antibody escape abilities of omicron variants.

ABSTRACT: Recent times witnessed an upsurge in the number of COVID19 cases which is primarily attributed to the emergence of several omicron variants, although there is substantial population vaccination coverage across the globe. Currently, many therapeutic antibodies have been approved for emergency usage. The present study critically evaluates the effect of mutations observed in several omicron variants on the binding affinities of different classes of RBD-specific antibodies using a combined approach of immunoinformatics and binding free energy calculations. Our binding affinity data clearly show that omicron variants achieve antibody escape abilities by incorporating mutations at the immunogenic hotspot residues for each specific class of antibody. K417N and Y505H point mutations are primarily

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC9395298 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature