PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression.

ABSTRACT:

Background

The mechanism underlying colorectal cancer (CRC) initiation and progression remains elusive, and overall survival is far from satisfactory. Previous studies have shown that PDGFA-associated protein 1 (PDAP1) is upregulated in several cancers including CRC. Here, we aimed to identify the cause and consequence of PDAP1 dysregulation in CRC and evaluate its role as a potential therapeutic target.

Methods

Multi-omics data analysis was performed to identify potential key players in CRC initiation and progression. Immunohistochemistry (IHC) staining was applied to determine the expression pattern of PDAP1 in CRC tissues. Pdap1 conditional knockout mice were used to establish colitis and CRC mouse models. RNA sequencing, a phosphoprotein antibody array, western blotting,

SUBMITTER: Cui HY 

PROVIDER: S-EPMC9395323 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature