Dataset Information

A single latent channel is sufficient for biomedical glottis segmentation.

ABSTRACT: Glottis segmentation is a crucial step to quantify endoscopic footage in laryngeal high-speed videoendoscopy. Recent advances in deep neural networks for glottis segmentation allow for a fully automatic workflow. However, exact knowledge of integral parts of these deep segmentation networks remains unknown, and understanding the inner workings is crucial for acceptance in clinical practice. Here, we show that a single latent channel as a bottleneck layer is sufficient for glottal area segmentation using systematic ablations. We further demonstrate that the latent space is an abstraction of the glottal area segmentation relying on three spatially defined pixel subtypes allowing for a transparent interpretation. We further provide evidence that the latent space is highly correlated with the glottal area waveform, can be encoded with four bits, and decoded using lean decoders while maintaining a high reconstruction accuracy. Our findings suggest that glottis segmentation is a task that can be highly optimized to gain very efficient and explainable deep neural networks, important for application in the clinic. In the future, we believe that online deep learning-assisted monitoring is a game-changer in laryngeal examinations.

SUBMITTER: Kist AM

PROVIDER: S-EPMC9395348 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A single latent channel is sufficient for biomedical glottis segmentation.

Kist Andreas M AM Breininger Katharina K Dörrich Marion M Dürr Stephan S Schützenberger Anne A Semmler Marion M

Scientific reports 20220822 1

Glottis segmentation is a crucial step to quantify endoscopic footage in laryngeal high-speed videoendoscopy. Recent advances in deep neural networks for glottis segmentation allow for a fully automatic workflow. However, exact knowledge of integral parts of these deep segmentation networks remains unknown, and understanding the inner workings is crucial for acceptance in clinical practice. Here, we show that a single latent channel as a bottleneck layer is sufficient for glottal area segmentati ...[more]

PMID: 35995933

Similar Datasets

Project description:The development of compact and energy-efficient wearable sensors has led to an increase in the availability of biosignals. To effectively and efficiently analyze continuously recorded and multidimensional time series at scale, the ability to perform meaningful unsupervised data segmentation is an auspicious target. A common way to achieve this is to identify change-points within the time series as the segmentation basis. However, traditional change-point detection algorithms often come with drawbacks, limiting their real-world applicability. Notably, they generally rely on the complete time series to be available and thus cannot be used for real-time applications. Another common limitation is that they poorly (or cannot) handle the segmentation of multidimensional time series. Consequently, the main contribution of this work is to propose a novel unsupervised segmentation algorithm for multidimensional time series named Latent Space Unsupervised Semantic Segmentation (LS-USS), which was designed to easily work with both online and batch data. Latent Space Unsupervised Semantic Segmentation addresses the challenge of multivariate change-point detection by utilizing an autoencoder to learn a 1-dimensional latent space on which change-point detection is then performed. To address the challenge of real-time time series segmentation, this work introduces the Local Threshold Extraction Algorithm (LTEA) and a "batch collapse" algorithm. The "batch collapse" algorithm enables Latent Space Unsupervised Semantic Segmentation to process streaming data by dividing it into manageable batches, while Local Threshold Extraction Algorithm is employed to detect change-points in the time series whenever the computed metric by Latent Space Unsupervised Semantic Segmentation exceeds a predefined threshold. By using these algorithms in combination, our approach is able to accurately segment time series data in real-time, making it well-suited for applications where timely detection of changes is critical. When evaluating Latent Space Unsupervised Semantic Segmentation on a variety of real-world datasets the Latent Space Unsupervised Semantic Segmentation systematically achieves equal or better performance than other state-of-the-art change-point detection algorithms it is compared to in both offline and real-time settings.

Project description:The objective investigation of the dynamic properties of vocal fold vibrations demands the recording and further quantitative analysis of laryngeal high-speed video (HSV). Quantification of the vocal fold vibration patterns requires as a first step the segmentation of the glottal area within each video frame from which the vibrating edges of the vocal folds are usually derived. Consequently, the outcome of any further vibration analysis depends on the quality of this initial segmentation process. In this work we propose for the first time a procedure to fully automatically segment not only the time-varying glottal area but also the vocal fold tissue directly from laryngeal high-speed video (HSV) using a deep Convolutional Neural Network (CNN) approach. Eighteen different Convolutional Neural Network (CNN) network configurations were trained and evaluated on totally 13,000 high-speed video (HSV) frames obtained from 56 healthy and 74 pathologic subjects. The segmentation quality of the best performing Convolutional Neural Network (CNN) model, which uses Long Short-Term Memory (LSTM) cells to take also the temporal context into account, was intensely investigated on 15 test video sequences comprising 100 consecutive images each. As performance measures the Dice Coefficient (DC) as well as the precisions of four anatomical landmark positions were used. Over all test data a mean Dice Coefficient (DC) of 0.85 was obtained for the glottis and 0.91 and 0.90 for the right and left vocal fold (VF) respectively. The grand average precision of the identified landmarks amounts 2.2 pixels and is in the same range as comparable manual expert segmentations which can be regarded as Gold Standard. The method proposed here requires no user interaction and overcomes the limitations of current semiautomatic or computational expensive approaches. Thus, it allows also for the analysis of long high-speed video (HSV)-sequences and holds the promise to facilitate the objective analysis of vocal fold vibrations in clinical routine. The here used dataset including the ground truth will be provided freely for all scientific groups to allow a quantitative benchmarking of segmentation approaches in future.

Dataset Information

A single latent channel is sufficient for biomedical glottis segmentation.

Publications

A single latent channel is sufficient for biomedical glottis segmentation.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets