Myeloma precursor disease (MGUS) among rescue and recovery workers exposed to the World Trade Center disaster.

ABSTRACT: An elevated risk of myeloma precursor disease, monoclonal gammopathy of undetermined significance (MGUS), was identified among Fire Department of the City of New York (FDNY) World Trade Center (WTC)-exposed firefighters. Further investigation was needed to determine if these findings were reproducible in a more heterogeneous WTC-exposed rescue/recovery workers cohort, the Stony Brook University-General Responder Cohort GRC (SBU-GRC). MGUS risk was compared between the cohorts and to published general population estimates from Olmsted County, MN, USA. In this observational seroprevalence study, odds ratios (OR) and age-standardized risk ratios (RR) of MGUS (M-spike and light-chain-MGUS combined), M-spike, and light-chain-MGUS were estimated using logistic regression. Age-standardized preval

SUBMITTER: Zeig-Owens R 

PROVIDER: S-EPMC9395354 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature