Serum matrix metalloproteinase 7 and accelerated glomerular filtration rate decline in a general non-diabetic population.

ABSTRACT:

Background

Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with GFR decline in a general non-diabetic population.

Methods

In the Renal Iohexol Clearance Survey, we measured GFR using iohexol clearance in 1627 subjects aged 50-64 years without self-reported diabetes, kidney or cardiovascular disease. After a median of 5.6 years, 1324 had follow-up GFR measurements. Using linear mixed models and logistic regression analyses, we evaluated the associati

SUBMITTER: Enoksen IT 

PROVIDER: S-EPMC9395374 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature