Phase I study of aflibercept in combination with docetaxel in Japanese patients with advanced solid malignancies.

ABSTRACT: Angiogenesis is a hallmark of cancer development. This study sought to determine the recommended dose of aflibercept, a recombinant fusion protein targeting VEGF-A, VEGF-B and placental growth factor (PlGF), combined with docetaxel in Japanese patients with advanced solid malignancies. This phase I study was planned to include 12 patients following a 3 + 3 algorithm to determine the maximum tolerated dose of aflibercept combined with docetaxel in patients with metastatic or unresectable solid tumors (trial registration: NCT00545246). Docetaxel (75 mg/m² every 3 weeks or 60 mg/m² after protocol amendment) was combined with escalating doses of aflibercept (2, 4 and 6 mg/kg every 4 weeks). Free and VEGF-bound aflibercept were measured to assess free aflibercept in excess

SUBMITTER: Sunakawa Y 

PROVIDER: S-EPMC9395466 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature