Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification.

ABSTRACT:

Objective

We previously reported a characterisation of the hepatocellular carcinoma (HCC) immune contexture and described an immune-specific class. We now aim to further delineate the immunogenomic classification of HCC to incorporate features that explain responses/resistance to immunotherapy.

Design

We performed RNA and whole-exome sequencing, T-cell receptor (TCR)-sequencing, multiplex immunofluorescence and immunohistochemistry in a novel cohort of 240 HCC patients and validated our results in other cohorts comprising 660 patients.

Results

Our integrative analysis led to define: (1) the inflamed class of HCC (37%), which includes the previously reported immune subclass (22%) and a new immune-like subclass (15%) with high interferon signalling, cytolytic activity,

SUBMITTER: Montironi C 

PROVIDER: S-EPMC9395551 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature